Ellence epirubicin hydrochloride dose, indications. Highlights of prescribing information given intravenously. It is also active in vivo against a variety of murine tumors and human xenografts in athymic mice, including breast tumors. Highlights of prescribing information these highlights do not include all the information needed to use cubicin safely and effectively. Iy12a epirubicin inj pi jan12 1 areva pharmaceuticals inc. Epirubicin 4epidoxorubicin is an antineoplastic agent derived from. Highlights of prescribing information these highlights do not include all the information needed to use ellence safely and effectively.
Epirubicin is an anthracycline antineoplastic agent whose mechanism of action. Highlights of prescribing information these highlights do not include all the information needed to use empliciti safely and effectively. Epirubicin fda prescribing information, side effects and. Pharmorubicin summary of product characteristics smpc. Ellence injection epirubicin hydrochloride injection is an anthracycline cytotoxic agent, intended for intravenous administration.
Ellence epirubicin hcl description pfizer medical information. Ellence epirubicin hydrochloride injection is an anthracycline topisomerase. Ellence is supplied as a sterile, clear, red solution and is available in polypropylene vials containing 50 and 200 mg of epirubicin hydrochloride as a preservativefree, readytouse solution. Epirubicin je organsko jedinjenje, koje sadrzi 27 atoma ugljenika i ima molekulsku masu od 543,519 da. Ellence epirubicin hydrochloride injection prescribing information.
Epirubicin is cytotoxic in vitro to a variety of established murine and human cell lines and primary cultures of human tumors. The incidence and severity was highest in patients receiving herceptin with anthracyclinecontaining chemotherapy regimens. The plasma concentration declined in a triphasic manner with mean halflives for the alpha, beta and gamma phases about 3. Epirubicin hydrochloride 2 mgml injection may be further diluted in glucose 5% or sodium chloride 0. Epirubicin hydrochloride for injection product monograph. Highlights of prescribing information initial dose of 4.
The use of epirubicin in combination chemotherapy with other potentially cardiotoxic drugs, as well as the concomitant use of other cardioactive compounds e. A dosedependent, reversible leukopenia andor neutropenia is the predominant manifestation of hematologic toxicity associated with epirubicin hydrochloride injection and. Highlights of prescribing information initial dose of. Highlights of prescribing information these highlights do not include all the information needed to use taxotere safely and effectively. Myocardial damage, including acute left ventricular failure, can occur with ellence. Daunorubicin hydrochloride injection must be given into a rapidly.
Epirubicin may increase your risk for developing leukemia cancer of the white blood cells, especially when it is given in high doses or together with certain other chemotherapy medications. See full prescribing information for complete boxed warning. Only for the use of a registered medical practitioner or a. These highlights do not include all the information needed to use erbituxsafely and effectively. Ellence epirubicin hydrochloride injection is an anthracycline topisomerase inhibitor for intravenous administration. Ellence is supplied as a sterile, clear, red solution and is available in polypropylene. Epirubicin side effects, dosage, interactions drugs. Each 20 mg vial contains 20 mg idarubicin hydrochloride, usp and 200 mg of lactose nf hydrous as an orangered, lyophilized powder. During treatment, you usually see a cancer doctor, a chemotherapy nurse or a specialist nurse, and a specialist pharmacist. Myocardial damage can occur with doxorubicin hydrochloride with incidences from 1% 20% for cumulative doses from.
Cardiomyopathy, infusion reactions, embryofetal toxicity, and pulmonary toxicity cardiomyopathy herceptin administration can result in subclinical and clinical cardiac failure. Myocardial damage can occur with doxorubicin hydrochloride with incidences from 1% 20% for cumulative doses from 300mgm2 to 500mgm2 when doxorubicin hydrochloride is administered every 3weeks. Any use of the information is subject, at all times, to ccos terms and. Full prescribing information 1 indications and usage valstar is an anthracycline topoisomerase inhibitor indicated for intravesical therapy of bcgrefractory carcinoma in situ cis of. Severe local tissue necrosis will occur if there is extravasation during. Idamycin idarubicin hydrochloride for injection, usp. Epirubicin is an anthracycline drug with the first clinical trial published in 1980. Epirubicin is a cancer medication that interferes with the growth and spread of cancer cells in the body. Highlights of prescribing information these highlights do not include all the information needed to use docetaxel safely and effectively. Highlights of prescribing information these highlights do not include all the information needed to use tecentriq safely and effectively.
Epirubicin indications, dosage, side effects and precautions. Patient information leaflet epirubicin hydrochloride 2 mg. Pfizer rxpathways connects eligible patients, regardless of their insurance status, to a range of assistance programs that offer insurance support, copay help, and medicines for free or at a savings. Epirubicin hydrochloride monograph for professionals. Cardiac toxicity, secondary malignancies, extravasation and tissue necrosis, and severe myelosuppression cardiac toxicity. Although it is known that anthracyclines can interfere with a number of. There is no conclusive information about epirubicin adversely affecting human fertility, or causing. Endometrial cancer, cardiovascular disorders, breast cancer and probable dementia estrogenalone therapy endometrial cancer there is an. Flolan epoprostenol sodium for injection, for intravenous use. For more information, please call 844 9897284 or visit eligible patients can register for valuable savings offers for nearly 40 brand name medications.
Epirubicin can be given in combination with other cancer drugs. Your doctor may prescribe oral antibiotics to help prevent infection. Epirubicin hydrochloride 2 mgml solution for injection or. Epirubicinellence generic is an anthracycline, prescribed for certain types of breast cancer. Daunorubicin hydrochloride injection rx only warnings 1. Epirubicin pharmacokinetics is linear over the dose range of 60150mgm2. Highlights of prescribing information these highlights do not include all the information needed to use herceptin safely and effectively.
Epirubicin hydrochloride for injection prescribing information. Epirubicin ebewe 2mgml solution for injection or infusion. It is favored over doxorubicin because of better efficacy and fewer. Epirubicin hydrochloride injection is provided in singledose vials containing 2 mg epirubicin hydrochloride per ml as a sterile, preservativefree, readytouse solution in the following sizes.
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